Alpha-GPC is a natural choline compound that works in two ways. On its own, it’s a respected nootropic known as a potent memory booster. When combined with other nootropics, it can take cognitive enhancement to a whole new level.

Alpha-GPC is the choline of choice for millions of nootropic users. It is considered by many as the best choline source on the market and an essential component in every nootropic stack.

Alpha-GPC also known as L-Alpha Glyceryl phosphorylcholine or Choline alphoscerate is a natural nootropic that works on its own and in combination with other nootropics. It is naturally present in the body in small amounts. It is commercially manufactured as an extract of purified soy lecithin. There are a few appreciable dietary sources of Alpha-GPC like some organ meats and wheat germ concentrates, but the intake amounts are far below these achieved through supplementation.

As an intermediate and in phospholipid metabolism, Alpha-GPC works rapidly and reliably primarily by delivering essential choline to the brain. Taken alone Alpha-GPC has significant nootropic properties including memory enhancement and protection against brain aging. Extensive clinical trials involving thousands of participants have shown to be effective against age-related memory loss associated with a variety of disorders including Alzheimer’s disease, vascular dementia, and stroke. It also has neuroprotective anti-aging capabilities and studies suggest it may also be useful in the treatment of anxiety.

Alpha-GPC has non-nootropic benefits as well including the ability to enhance cell membrane health and promote rapid recovery after physical exertion. Studies show that it may also act as a dopaminergic promoting the release of the hormone dopamine, which makes Alpha-GPC a potent mood enhancer. This has the potential for treating neurodegenerative conditions such as Parkinson’s disease.

For many nootropic users, the real strength of Alpha-GPC is its potentiating properties when taken in combination with other supplements. The additional choline that Alpha-GPC makes available to the brain can significantly amplify the cognitive enhancement effects of other ingredients in a nootropic stack.

Pros of using Alpha-GPC are:

  • Increased free choline levels in the brain, higher than Citicoline or Choline Bitrate
  • Promotes memory and synaptic plasticity
  • Supports brain cell health as a phospholipid source
  • Significantly improves cognition
  • Increases levels of Human Growth Hormone in athletes

Cons of using Alpha-GPC are:

  • It is more expensive than choline
  • It is highly hygroscopic (absorbs water from the air in bulk powder form; may solidify and form a gel)
  • Usually sold as 50% Alpha-GPC to reduce hygroscopicity


As one of the best nootropic stacks on the market, Nooflow® Absolute Mind contains 125mg Alpha-GPC 100% (AlphaSize® from Chemi Nutra). This is a 100% concentration of Alpha-GPC, which delivers more choline to the brain than 250mg Citicoline. Alpha-GPC 100%, in combination with the rest of the potent ingredients in Nooflow® Absolute Mind, make it one of the most powerful, yet balanced nootropic blends, which deliver many benefits such as improved short- and long-term memory, enhanced cognition and focus, improved mood and motivation.


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